Highlights and News

Rheumatoid arthritis: Pretreatment may delay onset by up to 4 years - Medical News Today
Rheumatoid arthritis: Pretreatment may delay onset by up to 4 years  Medical News Today
New gene study offers arthritis treatment insights - HealthandCare.scot
New gene study offers arthritis treatment insights  HealthandCare.scot
New research reveals shared genetic link between endometriosis and immune conditions - University of Oxford
New research reveals shared genetic link between endometriosis and immune conditions  University of Oxford
What Happens at the First Appointment With a Rheumatologist? - Everyday Health
What Happens at the First Appointment With a Rheumatologist?  Everyday Health
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis - Wiley Online Library
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis  Wiley Online Library
Links between arthritis therapy and heart disease improvements - University of Leeds
Links between arthritis therapy and heart disease improvements  University of Leeds
Study finds new treatment to reverse inflammation and arterial blockages in rheumatoid arthritis - Queen Mary University of London
Study finds new treatment to reverse inflammation and arterial blockages in rheumatoid arthritis  Queen Mary University of London
Gout incidence and management during the COVID-19 pandemic in England, UK: a nationwide observational study using OpenSAFELY - The Lancet
Gout incidence and management during the COVID-19 pandemic in England, UK: a nationwide observational study using OpenSAFELY  The Lancet
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients - Nature
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients  Nature
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank - Frontiers
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank  Frontiers
Editor's Pick: JAK Inhibitors in the Treatment Algorithm of Rheumatoid Arthritis: A Review - European Medical Journal
Editor's Pick: JAK Inhibitors in the Treatment Algorithm of Rheumatoid Arthritis: A Review  European Medical Journal
First UK patient treated in ‘OSCAR' COVID-19 research study, trialling experimental arthritis drug as treatment for coronavirus - Manchester University NHS Foundation Trust
First UK patient treated in ‘OSCAR' COVID-19 research study, trialling experimental arthritis drug as treatment for coronavirus  Manchester University NHS Foundation Trust
Foot and Ankle Care in Inflammatory Arthritis - Arthritis Foundation
Foot and Ankle Care in Inflammatory Arthritis  Arthritis Foundation
‘Milestone' as NICE recommends biologics in moderate rheumatoid arthritis for the first time - The Pharmaceutical Journal
‘Milestone' as NICE recommends biologics in moderate rheumatoid arthritis for the first time  The Pharmaceutical Journal
Refractory Inflammatory Arthritis definition and model generated through patient and multi-disciplinary professional modified Delphi process - medRxiv
Refractory Inflammatory Arthritis definition and model generated through patient and multi-disciplinary professional modified Delphi process  medRxiv
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis - The New England Journal of Medicine
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis  The New England Journal of Medicine
Asian and older rheumatoid arthritis sufferers 50% less likely to receive targeted treatment, finds study - Medical Xpress
Asian and older rheumatoid arthritis sufferers 50% less likely to receive targeted treatment, finds study  Medical Xpress
Rheumatoid arthritis - The Lancet
Rheumatoid arthritis  The Lancet
Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial - The Lancet
Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial  The Lancet
Trial suggests JAK1 inhibitor is superior to methotrexate for treatment of early rheumatoid arthritis - The Pharmaceutical Journal
Trial suggests JAK1 inhibitor is superior to methotrexate for treatment of early rheumatoid arthritis  The Pharmaceutical Journal
Rheumatoid Arthritis Life Expectancy: What You Need to Know - HealthCentral
Rheumatoid Arthritis Life Expectancy: What You Need to Know  HealthCentral
Osteoarthritis - World Health Organization (WHO)
Osteoarthritis  World Health Organization (WHO)
When to Go to the Hospital With Rheumatoid Arthritis Symptoms - HealthCentral
When to Go to the Hospital With Rheumatoid Arthritis Symptoms  HealthCentral
Blocking the immune system in rheumatoid arthritis - The Pharmaceutical Journal
Blocking the immune system in rheumatoid arthritis  The Pharmaceutical Journal
PsA Takes Longer to Diagnose and Gets Less Early Therapy Than RA - HealthCentral
PsA Takes Longer to Diagnose and Gets Less Early Therapy Than RA  HealthCentral
Rheumatoid arthritis diagnosis and management: a clinical update - Nursing Times
Rheumatoid arthritis diagnosis and management: a clinical update  Nursing Times
Association between obesity and remission in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs | Scientific Reports - Nature
Association between obesity and remission in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs | Scientific Reports  Nature
Moderate Psoriatic Arthritis and Perspectives from Phosphodiesterase-4 Inhibition - European Medical Journal
Moderate Psoriatic Arthritis and Perspectives from Phosphodiesterase-4 Inhibition  European Medical Journal
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission - Nature
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission  Nature
Tofacitinib versus Methotrexate in Rheumatoid Arthritis - The New England Journal of Medicine
Tofacitinib versus Methotrexate in Rheumatoid Arthritis  The New England Journal of Medicine
Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course - Nature
Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course  Nature
Rheumatoid arthritis and baking soda: The potential benefits - Medical News Today
Rheumatoid arthritis and baking soda: The potential benefits  Medical News Today
Psoriatic Arthritis in the Ankle: Could Your Ankle Pain Be a Sign of Psoriatic Arthritis? - CreakyJoints
Psoriatic Arthritis in the Ankle: Could Your Ankle Pain Be a Sign of Psoriatic Arthritis?  CreakyJoints
Rheumatoid Arthritis in the Wrist: Symptoms, Treatments and More - HealthCentral
Rheumatoid Arthritis in the Wrist: Symptoms, Treatments and More  HealthCentral
Efficacy of B-Cell-Targeted Therapy with Rituximab in Patients with Rheumatoid Arthritis - The New England Journal of Medicine
Efficacy of B-Cell-Targeted Therapy with Rituximab in Patients with Rheumatoid Arthritis  The New England Journal of Medicine
Therapies for Active Rheumatoid Arthritis after Methotrexate Failure - The New England Journal of Medicine
Therapies for Active Rheumatoid Arthritis after Methotrexate Failure  The New England Journal of Medicine
AVERT trial demonstrates high rates of DAS-defined remission with Orencia® (abatacept) in combination with Methotrexate in adult patients with early rheumatoid arthritis - Drug Target Review
AVERT trial demonstrates high rates of DAS-defined remission with Orencia® (abatacept) in combination with Methotrexate in adult patients with early rheumatoid arthritis  Drug Target Review
A life in dentistry - Meera Alagarajah on dealing with rheumatoid arthritis - Dentistry UK
A life in dentistry - Meera Alagarajah on dealing with rheumatoid arthritis  Dentistry UK
Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis - Nature
Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis  Nature
Peripheral blood cellular dynamics of rheumatoid arthritis treatment informs about efficacy of response to disease modifying drugs - Nature
Peripheral blood cellular dynamics of rheumatoid arthritis treatment informs about efficacy of response to disease modifying drugs  Nature
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics - Nature
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics  Nature
Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis - Nature
Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis  Nature
Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis - Nature
Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis  Nature
Treatment of Rheumatoid Arthritis by Selective Inhibition of T-Cell Activation with Fusion Protein CTLA4Ig - The New England Journal of Medicine
Treatment of Rheumatoid Arthritis by Selective Inhibition of T-Cell Activation with Fusion Protein CTLA4Ig  The New England Journal of Medicine
Rheumatoid arthritis cure: Is it possible? - Medical News Today
Rheumatoid arthritis cure: Is it possible?  Medical News Today
UK waiting times for RA and PsA patients: an interview with Dr Marwan Bukhari, Consultant Rheumatologist at the University Hospitals of Morecambe Bay NHS Foundation Trust - News-Medical
UK waiting times for RA and PsA patients: an interview with Dr Marwan Bukhari, Consultant Rheumatologist at the University Hospitals of Morecambe Bay NHS Foundation Trust  News-Medical
Osteoarthritis in primary care: early diagnosis and management - GPonline
Osteoarthritis in primary care: early diagnosis and management  GPonline
Carriers of HLA-DRB1*04:05 have a better clinical response to abatacept in rheumatoid arthritis - Nature
Carriers of HLA-DRB1*04:05 have a better clinical response to abatacept in rheumatoid arthritis  Nature
Rheumatoid arthritis - Nature
Rheumatoid arthritis  Nature
Early Treatment Boosts Long-term Rheumatoid Arthritis Outcomes - Medscape
Early Treatment Boosts Long-term Rheumatoid Arthritis Outcomes  Medscape
Psoriatic arthritis: New drug Bimzelx shows promise as treatment - Medical News Today
Psoriatic arthritis: New drug Bimzelx shows promise as treatment  Medical News Today
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients | Scientific Reports - Nature
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients | Scientific Reports  Nature
Ibuprofen for arthritis: Is it safe to take every day? - Medical News Today
Ibuprofen for arthritis: Is it safe to take every day?  Medical News Today
Severe arthritis pain treatments: an interview with Professor Walsh, University of Nottingham and Professor Wood, UCL - News-Medical
Severe arthritis pain treatments: an interview with Professor Walsh, University of Nottingham and Professor Wood, UCL  News-Medical
Treating rheumatoid arthritis with JAK inhibitors: What to know - Medical News Today
Treating rheumatoid arthritis with JAK inhibitors: What to know  Medical News Today
Early intensive treatment of rheumatoid arthritis offers an opportunity to manage fatigue - News-Medical
Early intensive treatment of rheumatoid arthritis offers an opportunity to manage fatigue  News-Medical
Rheumatoid Arthritis: Early Menopause, HRT May Raise Risk - Healthline
Rheumatoid Arthritis: Early Menopause, HRT May Raise Risk  Healthline
Rheumatoid arthritis: Early menopause among factors for higher risk - Medical News Today
Rheumatoid arthritis: Early menopause among factors for higher risk  Medical News Today
Shingles Symptoms, Causes, and Treatments - WebMD
Shingles Symptoms, Causes, and Treatments  WebMD
Rheumatoid arthritis: Could a test tell which biologic may be best? - Medical News Today
Rheumatoid arthritis: Could a test tell which biologic may be best?  Medical News Today
Turmeric for rheumatoid arthritis: Does it work? - Medical News Today
Turmeric for rheumatoid arthritis: Does it work?  Medical News Today
Weather, seasons, and rheumatoid arthritis flares - Medical News Today
Weather, seasons, and rheumatoid arthritis flares  Medical News Today
Rheumatoid Arthritis: Common Questions About Diagnosis and Management - American Academy of Family Physicians | AAFP
Rheumatoid Arthritis: Common Questions About Diagnosis and Management  American Academy of Family Physicians | AAFP
Hydroxychloroquine for rheumatoid arthritis: Uses and more - Medical News Today
Hydroxychloroquine for rheumatoid arthritis: Uses and more  Medical News Today
Minocycline for rheumatoid arthritis: What to know - Medical News Today
Minocycline for rheumatoid arthritis: What to know  Medical News Today
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure' - Healio
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure'  Healio
Differentiating Rheumatoid and Psoriatic Arthritis of the Hand: Multimodality Imaging CharacteristicsRadioGraphics - RSNA Journals
Differentiating Rheumatoid and Psoriatic Arthritis of the Hand: Multimodality Imaging CharacteristicsRadioGraphics  RSNA Journals
Treatments for rheumatoid arthritis: Traditional DMARDS vs. biologics - Medical News Today
Treatments for rheumatoid arthritis: Traditional DMARDS vs. biologics  Medical News Today
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis - The New England Journal of Medicine
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis  The New England Journal of Medicine
Chinese herbal remedy 'just as effective as methotrexate against arthritis' - Medical News Today
Chinese herbal remedy 'just as effective as methotrexate against arthritis'  Medical News Today
Ankylosing spondylitis: an update - Royal Australian College of General Practitioners (RACGP)
Ankylosing spondylitis: an update  Royal Australian College of General Practitioners (RACGP)
England | London | Six taken ill after drug trials - BBC
England | London | Six taken ill after drug trials  BBC
Blood test could provide an early arthritis warning - Nursing Times
Blood test could provide an early arthritis warning  Nursing Times
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis - The New England Journal of Medicine
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis  The New England Journal of Medicine
New blood test promises to give up to 16 years' warning of arthritis - Daily Mail
New blood test promises to give up to 16 years' warning of arthritis  Daily Mail

Articles/peer reviewed publications and
Lay Summaries

  • B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure.
    Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C; PEAC- R4RA investigators. 
    Arthritis Rheumatol. 2019 Nov 29.
    https://doi.org/10.1002/art.41184
    See Lay Summary




The R4-RA trial is funded by the MRC-NIHR Efficacy and
Mechanism Evaluation Programme