Highlights and News

New gene study offers arthritis treatment insights - HealthandCare.scot
New gene study offers arthritis treatment insights  HealthandCare.scot
Methotrexate oral or subcutaneous for rheumatoid arthritis (MOOSE): study protocol for a multi-centre randomised trial - SpringerLink
Methotrexate oral or subcutaneous for rheumatoid arthritis (MOOSE): study protocol for a multi-centre randomised trial  SpringerLink
New research reveals shared genetic link between endometriosis and immune conditions - University of Oxford
New research reveals shared genetic link between endometriosis and immune conditions  University of Oxford
Is There a Missing Link in Rheumatoid Arthritis Management? - EMJ
Is There a Missing Link in Rheumatoid Arthritis Management?  EMJ
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis - Wiley Online Library
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis  Wiley Online Library
Links between arthritis therapy and heart disease improvements - University of Leeds
Links between arthritis therapy and heart disease improvements  University of Leeds
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial - The Lancet
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial  The Lancet
The 4 Stages of Rheumatoid Arthritis Progression - CreakyJoints
The 4 Stages of Rheumatoid Arthritis Progression  CreakyJoints
Refractory Inflammatory Arthritis definition and model generated through patient and multi-disciplinary professional modified Delphi process - medRxiv
Refractory Inflammatory Arthritis definition and model generated through patient and multi-disciplinary professional modified Delphi process  medRxiv
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank - Frontiers
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank  Frontiers
Arthritis drug effective in treating sickest COVID-19 patients - Imperial College London
Arthritis drug effective in treating sickest COVID-19 patients  Imperial College London
Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial - Nature
Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial  Nature
Understanding Methotrexate - Arthritis Foundation
Understanding Methotrexate  Arthritis Foundation
First UK patient treated in ‘OSCAR' COVID-19 research study, trialling experimental arthritis drug as treatment for coronavirus - Manchester University NHS Foundation Trust
First UK patient treated in ‘OSCAR' COVID-19 research study, trialling experimental arthritis drug as treatment for coronavirus  Manchester University NHS Foundation Trust
Biological treatment in rheumatoid arthritis: when to stop? - The Lancet
Biological treatment in rheumatoid arthritis: when to stop?  The Lancet
Editor's Pick: JAK Inhibitors in the Treatment Algorithm of Rheumatoid Arthritis: A Review - EMJ
Editor's Pick: JAK Inhibitors in the Treatment Algorithm of Rheumatoid Arthritis: A Review  EMJ
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients - Nature
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients  Nature
Gout incidence and management during the COVID-19 pandemic in England, UK: a nationwide observational study using OpenSAFELY - The Lancet
Gout incidence and management during the COVID-19 pandemic in England, UK: a nationwide observational study using OpenSAFELY  The Lancet
Rheumatoid arthritis - The Lancet
Rheumatoid arthritis  The Lancet
Foot and Ankle Care in Inflammatory Arthritis - Arthritis Foundation
Foot and Ankle Care in Inflammatory Arthritis  Arthritis Foundation
Rheumatoid Arthritis Life Expectancy: What You Need to Know - HealthCentral
Rheumatoid Arthritis Life Expectancy: What You Need to Know  HealthCentral
Rheumatoid arthritis diagnosis and management: a clinical update - Nursing Times
Rheumatoid arthritis diagnosis and management: a clinical update  Nursing Times
Blocking the immune system in rheumatoid arthritis - The Pharmaceutical Journal
Blocking the immune system in rheumatoid arthritis  The Pharmaceutical Journal
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis - New England Journal of Medicine
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis  New England Journal of Medicine
Rheumatoid arthritis - The Lancet
Rheumatoid arthritis  The Lancet
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment - Nature
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment  Nature
Efficacy of B-Cell-Targeted Therapy with Rituximab in Patients with Rheumatoid Arthritis - New England Journal of Medicine
Efficacy of B-Cell-Targeted Therapy with Rituximab in Patients with Rheumatoid Arthritis  New England Journal of Medicine
Osteoarthritis - World Health Organization (WHO)
Osteoarthritis  World Health Organization (WHO)
2023 Management Recommendations of Bangladesh Rheumatology Society on Pharmacological Treatment of Rheumatoid Arthritis With Synthetic and Biologic Disease-Modifying Drugs - Cureus
2023 Management Recommendations of Bangladesh Rheumatology Society on Pharmacological Treatment of Rheumatoid Arthritis With Synthetic and Biologic Disease-Modifying Drugs  Cureus
Rheumatoid Arthritis & Jaw Pain: Here's How to Deal - HealthCentral
Rheumatoid Arthritis & Jaw Pain: Here's How to Deal  HealthCentral
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission - Nature
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission  Nature
Association between obesity and remission in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs | Scientific Reports - Nature
Association between obesity and remission in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs | Scientific Reports  Nature
Rheumatoid arthritis cure: Is it possible? - Medical News Today
Rheumatoid arthritis cure: Is it possible?  Medical News Today
Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course | Scientific Reports - Nature
Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course | Scientific Reports  Nature
Psoriatic Arthritis in the Ankle: Could Your Ankle Pain Be a Sign of Psoriatic Arthritis? - CreakyJoints
Psoriatic Arthritis in the Ankle: Could Your Ankle Pain Be a Sign of Psoriatic Arthritis?  CreakyJoints
AVERT trial demonstrates high rates of DAS-defined remission with Orencia® (abatacept) in combination with Methotrexate in adult patients with early rheumatoid arthritis - Drug Target Review
AVERT trial demonstrates high rates of DAS-defined remission with Orencia® (abatacept) in combination with Methotrexate in adult patients with early rheumatoid arthritis  Drug Target Review
Therapies for Active Rheumatoid Arthritis after Methotrexate Failure - New England Journal of Medicine
Therapies for Active Rheumatoid Arthritis after Methotrexate Failure  New England Journal of Medicine
Osteoarthritis in primary care: early diagnosis and management - GPonline
Osteoarthritis in primary care: early diagnosis and management  GPonline
Rheumatoid arthritis begins years before symptoms, study finds - Medical News Today
Rheumatoid arthritis begins years before symptoms, study finds  Medical News Today
Rheumatoid arthritis and baking soda: The potential benefits - Medical News Today
Rheumatoid arthritis and baking soda: The potential benefits  Medical News Today
Exercises to improve function of the rheumatoid hand (SARAH): a randomised controlled trial - The Lancet
Exercises to improve function of the rheumatoid hand (SARAH): a randomised controlled trial  The Lancet
Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: A randomized, controlled trial - Wiley Online Library
Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: A randomized, controlled trial  Wiley Online Library
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics - Nature
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics  Nature
Tocilizumab - a new treatment for severe juvenile idiopathic arthritis in children | Research Impact - UCL - University College London
Tocilizumab - a new treatment for severe juvenile idiopathic arthritis in children | Research Impact - UCL  University College London
Rheumatoid arthritis - Nature
Rheumatoid arthritis  Nature
Rheumatoid Arthritis of the Cervical Spine: Background, Pathophysiology, Epidemiology - Medscape
Rheumatoid Arthritis of the Cervical Spine: Background, Pathophysiology, Epidemiology  Medscape
Is Vagus Nerve Stimulation the Future for RA Treatment? - HealthCentral
Is Vagus Nerve Stimulation the Future for RA Treatment?  HealthCentral
New drug Bimzelx shows promise as a treatment for psoriatic arthritis - Medical News Today
New drug Bimzelx shows promise as a treatment for psoriatic arthritis  Medical News Today
Pharmaceutical care in rheumatoid arthritis - Hospital Pharmacy Europe
Pharmaceutical care in rheumatoid arthritis  Hospital Pharmacy Europe
What Happens at the First Appointment With a Rheumatologist? - Everyday Health
What Happens at the First Appointment With a Rheumatologist?  Everyday Health
Early Treatment Boosts Long-term Rheumatoid Arthritis Outcomes - Medscape
Early Treatment Boosts Long-term Rheumatoid Arthritis Outcomes  Medscape
A New Study Sheds Light on the Early Roots of RA - HealthCentral
A New Study Sheds Light on the Early Roots of RA  HealthCentral
Carriers of HLA-DRB1*04:05 have a better clinical response to abatacept in rheumatoid arthritis - Nature
Carriers of HLA-DRB1*04:05 have a better clinical response to abatacept in rheumatoid arthritis  Nature
Rheumatoid arthritis: How to spot arthritis bumps - location and size - Daily Express
Rheumatoid arthritis: How to spot arthritis bumps - location and size  Daily Express
22 natural treatments for psoriatic arthritis - Medical News Today
22 natural treatments for psoriatic arthritis  Medical News Today
"A very Cambridge story" - University of Cambridge
"A very Cambridge story"  University of Cambridge
Treating rheumatoid arthritis with JAK inhibitors: What to know - Medical News Today
Treating rheumatoid arthritis with JAK inhibitors: What to know  Medical News Today
Ibuprofen for arthritis: Is it safe to take every day? - Medical News Today
Ibuprofen for arthritis: Is it safe to take every day?  Medical News Today
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients - Nature
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients  Nature
Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health - Nature
Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health  Nature
Rheumatoid arthritis: Could a test tell which biologic may be best? - Medical News Today
Rheumatoid arthritis: Could a test tell which biologic may be best?  Medical News Today
Rheumatoid arthritis: Early menopause among factors for higher risk - Medical News Today
Rheumatoid arthritis: Early menopause among factors for higher risk  Medical News Today
Rheumatoid Arthritis: Common Questions About Diagnosis and Management - American Academy of Family Physicians | AAFP
Rheumatoid Arthritis: Common Questions About Diagnosis and Management  American Academy of Family Physicians | AAFP
Early Menopause, Hormone Replacement Therapy May Raise Rheumatoid Arthritis Risk - Healthline
Early Menopause, Hormone Replacement Therapy May Raise Rheumatoid Arthritis Risk  Healthline
Turmeric for rheumatoid arthritis: Does it work? - Medical News Today
Turmeric for rheumatoid arthritis: Does it work?  Medical News Today
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure' - Healio
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure'  Healio
Blood test could provide an early arthritis warning - Nursing Times
Blood test could provide an early arthritis warning  Nursing Times
Rheumatoid arthritis symptoms: Sweating, dry eyes and other surprising symptoms - Daily Express
Rheumatoid arthritis symptoms: Sweating, dry eyes and other surprising symptoms  Daily Express
Treatments for rheumatoid arthritis: Traditional DMARDS vs. biologics - Medical News Today
Treatments for rheumatoid arthritis: Traditional DMARDS vs. biologics  Medical News Today
How does alcohol affect rheumatoid arthritis (RA)? - Medical News Today
How does alcohol affect rheumatoid arthritis (RA)?  Medical News Today
Triple Treatment Effective in Early Rheumatoid Arthritis - Medscape
Triple Treatment Effective in Early Rheumatoid Arthritis  Medscape
Benefits and side effects of LDN for rheumatoid arthritis - Medical News Today
Benefits and side effects of LDN for rheumatoid arthritis  Medical News Today
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis - New England Journal of Medicine
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis  New England Journal of Medicine
Chinese herbal remedy 'just as effective as methotrexate against arthritis' - Medical News Today
Chinese herbal remedy 'just as effective as methotrexate against arthritis'  Medical News Today
Ankylosing spondylitis: an update - Royal Australian College of General Practitioners (RACGP)
Ankylosing spondylitis: an update  Royal Australian College of General Practitioners (RACGP)
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis - New England Journal of Medicine
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis  New England Journal of Medicine

Articles/peer reviewed publications and
Lay Summaries

  • B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure.
    Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C; PEAC- R4RA investigators. 
    Arthritis Rheumatol. 2019 Nov 29.
    https://doi.org/10.1002/art.41184
    See Lay Summary




The R4-RA trial is funded by the MRC-NIHR Efficacy and
Mechanism Evaluation Programme